Molecular Epidemiology of Vitamin D Receptor Gene Variants
نویسندگان
چکیده
منابع مشابه
Molecular epidemiology of vitamin D receptor gene variants.
The vitamin D receptor (VDR) is a ligand-activated transcription factor that mediates the genomic effects of 1,25dihydroxyvitamin D in a wide variety of tissues. The gene encoding the VDR is located on chromosome 12q and has several common allelic variants. The individual allelic variants and their haplotypes have been widely studied as markers of susceptibility to osteoporosis, a prevalent met...
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Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Several studies have shown that ALL occurs as a result of genetic abnormalities. 1, 25-Dihydroxyvitamin D3 as a secosteroid hormone plays an important role in different metabolic pathways. The normal function of vitamin D occurs via binding to a ligand-activated transcription factor i.e. vitamin D receptor (VDR)...
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Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients w...
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BACKGROUND Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS. OBJECTIVE The present study was designed to investigate the possible associations between polymorphisms in VDR, PTH, and INSR ge...
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Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes. Vitamin D acts via its receptor (VDR). Four single nucleotide polymorphisms (SNPs) of the VDR gene have been commonly studied, and evidence of association with type 1 diabetes has been reported previously. We sequenced the VDR gene region and developed its SNP map. ...
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ژورنال
عنوان ژورنال: Epidemiologic Reviews
سال: 2000
ISSN: 0193-936X,1478-6729
DOI: 10.1093/oxfordjournals.epirev.a018033